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Changes in AP duration (APD) measured to 50% (above left) and 90% repolarization (below left) of epicardial muscle fibers with increasing time after coronary artery occlusion [5] . Mean values±S.D. are shown by columns for the first layer of muscle fibers beneath the epicardial surface in normal noninfarcted preparations (striped columns) and in each group of infarcted preparations (solid columns) studied at the times indicated on the abscissa. Asterisks denote values significantly different from control. At the right are shown representative transmembrane potential recordings; (A) normal; (B) 1 day; (C) 5 days; (D) 2 weeks; (E) 2 months. Note that APs in the 1- and 5-day-old infarcts show loss of the plateau phase during repolarization. Action potential duration is decreased more in 5-day-old than in 1-day-old infarcts. Reproduced from [5] .

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Changes in AP duration (APD) measured to 50% (above left) and 90% repolarization (below left) of epicardial muscle fibers with increasing time after coronary artery occlusion [5] . Mean values±S.D. are shown by columns for the first layer of muscle fibers beneath the epicardial surface in normal noninfarcted preparations (striped columns) and in each group of infarcted preparations (solid columns) studied at the times indicated on the abscissa. Asterisks denote values significantly different from control. At the right are shown representative transmembrane potential recordings; (A) normal; (B) 1 day; (C) 5 days; (D) 2 weeks; (E) 2 months. Note that APs in the 1- and 5-day-old infarcts show loss of the plateau phase during repolarization. Action potential duration is decreased more in 5-day-old than in 1-day-old infarcts. Reproduced from [5] .

The origin of the delayed phase of spontaneous arrhythmias secondary to coronary artery occlusion in canine and porcine hearts is most likely in the depolarized and abnormally automatic subendocardial Purkinje fibers that survive. The loss of resting potential is significant and dramatic in the multicellular preparations of these fibers. Concomitant with this dramatic loss is a reduction in intracellular K + ion concentration ( a K i ). However, a decrease in K + equilibrium potential ( E K ) (average change 16 mV) cannot fully account for the loss in resting potential (average change 35 mV) [6] .

Abnormalities in the resting potentials of subendocardial Purkinje fibers surviving in the infarcted heart persist even after they are enzymatically disaggregated and studied as single myocytes [7] . In the myocyte, a reduction in a K i could not provide the basis for the reduced resting potential. Rather, Purkinje myocytes isolated from the infarcted myocardium show an increase in the ratio of the membrane permeability of Na + to K + ions ( P Na / P K ) as compared to control. The larger value of P Na / P K in these cells could be due to an increase in P Na or a decrease in P K or both. Input resistance measurements suggest that the subendocardial Purkinje myocytes from the infarcted myocardium have higher input resistances than control cells. This is in agreement with a multicellular study on these fiber bundles [8] . Combined with the P Na / P K measurements in the myocytes, it is likely that there is a net decrease in P K in the cells with reduced resting potentials. Finally, this is consistent with a decrease in the density of both the outward K + current and inward rectifying K + current, I K1 , recently described for the Purkinje myocytes surviving in the 48-h infarcted heart [9] .

A key issue in the interpretation of the limited positive findings for meningioma is whether the elevated point estimates of risk in the higher exposure categories are based on unusually low risks in the lowest exposure category or unusually high risks in the higher exposure categories, or both. The comparisons with national cancer registration rates suggest that the former is at least partly responsible, and taken together with the lower than average rates of meningioma in the total cohort under study, these findings argue against a causative explanation for the elevated risks obtained from the Poisson regression (internal) analyses.

The study has many strengths including its large size, long period of follow-up, availability of cancer registration as well as mortality data, large number of glioma cases available for analysis and detailed exposure assessments that used the physics of exposure to magnetic fields as a starting point [ 10 ]. However, there are limitations to be attached to the work. Most notably, it was necessary to assume that for those workers hired before 1973, job and place of work in the 1950s and 1960s were the same as those pursued in the early 1970s, and it was also assumed that working patterns (time spent by different groups of workers in different parts of power stations) are the same in different power stations. These assumptions will have introduced errors into the exposure assessments, but we remain confident that the exposure assessments have value particularly if we accept the relative rankings of the five exposure categories and do not attach overwhelming importance to their absolute values. It must be the case, however, that the current exposure estimates fall short of an ideal survey that would include measured individual exposures over time.

Earlier published comparisons with national mortality rates (total cohort and males and females combined) are consistent with the absence of occupational risk factors for the generality of brain tumours (Obs 202, SMR 107, 95% CI: 93–123) [ 13 ]. Likewise, earlier comparisons with national incidence rates (total cohort and males and females combined) are also consistent with the absence of occupational risk factors for the generality of malignant brain tumours (Obs 278, SRR 100, 95% CI: 88–114) and for the generality of other brain tumours (benign, in situ , unspecified behaviour) (Obs 93, SRR 93, 95% CI: 75–114) [ 14 ]. These SRRs are similar to the published findings for all malignant neoplasms (Obs 15 103, SRR 96, 95% CI: 95–98) [ 14 ] and to the overall SRR for meningioma shown in this report (Obs 41, SRR 90, 95% CI: 64–122). National comparisons will be subject to many influences including regional and socio-economic effects and employment selection effects such as the healthy worker effect, although the latter would be expected to have more influence on mortality than cancer incidence. The overall SRR for all malignant neoplasms suggests, however, that national comparisons are meaningful for this cohort; the low SRR for meningioma in the baseline group may well be no more than a chance finding.

Health Behavior Research in the Age of Personalized Medicine

The American Academy of Health Behavior invites abstracts to be considered for poster research presentations at the 2017 annual meeting March 19-22, 2017 in Tucson, Arizona. The meeting theme: Health Behavior Research in the Age of Personalized Medicine highlights the need for public health practitioners and medical personnel to collaboratively migrate towards a tailored approach to health and well-being by accounting for unique personal characteristics (i.e., genetics, social and environmental risk factors) and individual responses to interventions. Personalized medicine has the potential to alter the way health problems are studied and managed, which can ultimately advance public and behavioral health.

poster research presentations

General Guidelines

We particularly encourage research abstracts related to the theme of the meeting; however, abstracts related to other health behavior topics and settings are welcome for submission. Preference will be given to quantitative and qualitative research-based abstracts that report complete results. Abstracts are limited to 300 words (i.e., body of abstract). Please be sure to check the word count before submitting as only the first 300 words will be considered for review.

Researchers can submit no more than 3 first-author abstract submissions. Co-authorship is unlimited. If a person submits more than 3 first-author abstracts, that person will be asked by the Abstract Review Chair to choose which 3 abstracts they would like reviewed.

No Show Policy: Any cancellations for abstract presentations must be due to professional and/or personal/family health emergencies and be made directly to the AAHB Research Review Chair. Cancellations must be made prior to the first day of the Annual Meeting. All those violating this policy will be subject to a one-year probation period during which they may not submit an abstract for presentation at an AAHB annual meeting.

Abstract Deadline: September 27, 2016 at 11:59 p.m., PST .

Abstract Deadline: September 27, 2016 at 11:59 p.m., PST

Both member and non-members are encouraged to submit abstracts for the meeting. Authors will be notified of the status of their submission(s) by November 7, 2016. If your abstract is accepted, it is expected that you or a co-author will register for the meeting and be present for the session.

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I think it was in Herbert Blix’s book (but I can’t be positive- I read this a few years ago) that stated that after the Russians invaded Manchuria, Hirohito became convinced that the IJA couldn’t protect the country anymore and that that was a big reason why he wanted to surrender. The officers who inspected the bomb’s damage noted that the effects were felt no more than a foot down into the soil, therefore Japanese citizens should dig shelters to protect themselves from future blasts. The Japanese officers wanted the Americans to invade so that the Japanese could die glorious deaths in battle…

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This is an interesting and actually quite older debate than most people realize. The United States Strategic Bombing Survey summary report from mid-1946, for example, Johannes W Women’s Agnetha Ankle Boots Grey Antracita clearance finishline under online discount best sale clearance low shipping 9FB4LRkupX
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Yes! I’ve read the survey, too. And didn’t Leahy say that the United States Navy, with a little help from the army (air corps, I presume), had already defeated Japan (with the blockade)? There would have been mass starvation that winter and the emperor would likely have been overthrown- at least he feared a rebellion. And poor Truman- imagine if the Republicans found out that he had spent $2B on a weapon that WAS NEVER USED…

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Well, it was Roosevelt who spent the money, not Truman. The postwar “what if it doesn’t work” question kept Groves up at night, but I don’t think it did Truman —it never occurred to him not to use the bomb.

There are complicated historical reasons why the conventional military men liked to dismiss the bomb, especially in the postwar. They feared (for awhile) that it would make them irrelevant, or overshadow their own contributions. So they tended to play it down, rightly or wrongly.

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The key to this whole question is the fact of city bombing. Once you accept a sustained campaign of city bombing as as a valid act of warfare, there’s not much difference between one B-29 with a 20 kiloton nuke and a fleet of B-29s with conventional bombs. We eventually had both, but there were hardly any targets left by the time the nukes arrived on the scene.

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